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The development of the immune system in the first 1000 days of life

The immune system develops quickly during the first 1000 days of life; it is well known that both the establishment and maintenance of an optimal microbial community is important for the development of the immune system and essential to maintain health, especially in infants and children.1


Environmental factors such as mode of delivery, diet and use of antibiotics influence the infant gut and immune system. These factors can cause an imbalance of the gut microbiota known as dysbiosis, which impairs the development of the immune system, resulting in a state of inflammation and potentially giving rise to allergic diseases.2

Dysbiosis model
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The role of the gut microbiota on allergy development in early life


The importance of early life nutrition in the prevention and dietary management of CMA

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Dr Adam Fox: Effective ways to positively influence the gut microbiota

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Professor Nikos Papadopoulos: The long term implications of gut dysbiosis

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The role of synbiotics in allergy management

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Professor Jan Knol: Gut microbiota and the development of the immune system